In recent years, advances in imaging probes, microscopy techniques and bioinformatics image analysis have markedly expanded the imaging toolbox available to biologists. Apart from conventional phenotypic studies, embryonic development and disease progressing are increasingly investigated in vivo with improved accuracy in time and space and more detailed quantitative analyses down to the single-cell level (reviewed here).
To get more insight into the elaborate cell dynamics (i.e. cell division, motility and morphological changes) and protein dynamics (i.e. turnover and kinetics of key factors), the Laboratory of Nano Bio Imaging addresses the growing imaging needs of the biological community by developing assays (FDAP), cutting-edge imaging technologies (Primed Conversion), and reagents (SHG Nanoprobes) for carrying out in vivo imaging with i) high spatiotemporal resolution from the tissue level down to the single-cell level and with ii) sensitivities down to individual proteins.
Such newly introduced and future imaging tools can then be used as a means of performing qualitative and quantitative imaging in order to mechanistically dissect development, disease progression, and tissue regeneration.